How do hormonal changes during menopause interact with the gut microbiome to shape long-term health?
AGEWISE is a translational research initiative exploring how menopause influences the gut microbiome and how these changes may contribute to symptom variability and chronic disease risk.
Learn About the ProjectAGEWISE investigates the interaction between:
Female sex hormones
The gut microbiome
Systemic inflammation
Age-related disease risk
During the menopausal transition, women experience profound biological changes. Alongside hormonal shifts, the risk of cardiovascular disease, metabolic disorders and other chronic conditions increases.
Emerging research suggests that the gut microbiome - the community of microorganisms living in our intestines - may play an important role in regulating inflammation, metabolism and even brain function during this transition.
However, many mechanisms remain poorly understood.
Assessment of participants’ clinical history, menopausal status, symptoms, anthropometric measures, and relevant health/lifestyle factors.
Comprehensive characterization of circulating hormone-related metabolites using metabolomics to capture endocrine changes across the menopausal transition.
Quantification of systemic inflammatory biomarkers, including CRP and IL-6, using ELISA-based assays.
Characterization of gut microbial composition and diversity to identify microbiome patterns associated with menopausal status and clinical features.
Joint analysis of clinical, hormonal, inflammatory, and microbiome data using multivariate/statistical modelling to identify cross-domain patterns, associations, and potential predictors.
We periodically organise open days and recruitment sessions for women interested in contributing to menopause research.
When recruitment is open, details will be available here.
Eligibility criteria and study information will be provided during recruitment periods.
